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By understanding that one creates the pathways and the other moves the builders, researchers can perfectly align their choice with their experimental endpoints, resulting in unparalleled regenerative data

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In murine EpSCs, inflammatory signals activate STAT3, which translocates to the nucleus and binds H3K4me1- and H3K27ac-marked chromatin, establishing an epigenetically poised state ( in vitro : in -glucantrained monocytes, promoters and enhancers of inflammation- and immunity-related genes gain H3K4me1, H3K4me3, and H3K27ac marks, maintaining transcriptionally active chromatin and enabling enhanced cytokine production upon restimulation (153)